2018/12/01 Full-field Optical Coherence Tomography: A New Imaging Modality for Rapid On-Site Evaluation of Resected Polyps During Colonoscopy

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2018/12/01 Full-field Optical Coherence Tomography: A New Imaging Modality for Rapid On-Site Evaluation of Resected Polyps During Colonoscopy

Marine Camus, Frederic Beuvon, Maximilien Barret, Eugenie Dalimier,
Hicham El Bacha, Sarah Leblanc, Romain Coriat, Stanislas Chaussade, Benoit Terris, and Frederic Prat

A “characterize, resect, and discard” strategy has been proposed as a new approach, allowing more expeditious and efficient management of the patient with colonic polyps as well as histologic procedure cost savings. However, despite recent advances, the technologies embedded in currently available endoscopes have not proven to be sufficiently reliable to implement that strategy in the routine endoscopic practice. 1 Full-field optical coherence tomography (FFOCT) is an emerging optical technique for the rapid evaluation of tissue architecture. 2 FFOCT has been used to image fresh and fixed human tissues such as skin, 3 cornea, 4 brain, 5 and even pancreatic biopsy specimens. 6 FFOCT might prove useful during colonoscopy, when a rapid on-site assessment of tissue architecture can determine whether to discard polyps and immediately advise patients on subsequent surveillance or to warrant further histologic analysis. Here, we present the technical feasibility of ex vivo FFOCT imaging on colonic polyps and its ability to visualize cellular and architectural features of normal and neoplastic colonic tissue.

Full publication: https://www.gastrojournal.org/article/S0016-5085(18)34976-X/abstract

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